Genes, Macromolecules, -&- Computing are Strange Loops

I began thinking about the concepts presented in this work from around the age of 12, in 1984, as I read and reread Gödel, Escher, Bach: An Eternal Golden Braid by Douglas Hofstadter. I started writing when I had learnt enough to form a reasonably cogent and coherent sentences. This occurred when I was 17, in 1990, when I began my undergraduate degrees in Computing Science and Genetics (with minors in Mathematics and Microbiology). Since then I didn't come back to it since I laid most of the ideas I had then and what I thought would take me months or years (the protein folding problem) consumed my life and then some.

The book thus is an ongoing process. The other chapters will be published as they're written. The reason for the hold up is because solving the protein folding problem is highly nontrivial. I've realised methods I've proposed will not work and I am trying new approaches. Thus the reason for the delay in including the chapters that go into details. If nothing, it should make for some thought provoking reading (along the lines of certain pop science books).

Incidentally, some of the ideas stated here (simulating an artificial cell in molecular detail in virtuale, for example) have actually begun to be thought about seriously in science (1997), but those ideas were proposed in this work as early as 1992-93 and were thought about in the roughest forms in 1984.


Contents

  1. Overview
  2. It's a small molecule world after all
  3. Transcribing DNA
  4. Translating mRNA
  5. Protein folding
  6. The cell as an emergent self replicating and self organising operating system
  7. Philosophical issues
  8. Reflections

Related


Genes, Macromolecules, -&- Computing || Pseudointellectual ramblings || Ram Samudrala || me@ram.org